One of the most common reasons that we've found for this is that there are often more than one serial driver installed on the machine. Its worth uninstalling all the serial drivers you can find on the machine in question, and ensuring that the one driver that gets installed is the one for your adaptor.
Some manufacturers are lazy and bundle a load of their 'popular' drivers into one install.
I have never ever ever had a problem with the USB->Serial adaptors that Easy Sync sell:
http://www.easysync.co.uk/